Saturday, July 7, 2012

Activists Call for NIH Research Chimps to Be Retired

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In the wake of a 2011 federal report concluding that chimp research is scientifically unnecessary, an animal-rights group wants the NIH director to to ensure that chimps still in agency labs are retired


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From Nature magazine

Loretta, Ricky, Tiffany and Torian lead increasingly quiet lives, munching peppers and plums, perching and swinging in their 16-cubic-metre glass enclosures. They are the last four chimpanzees at Bioqual, a contract firm in Rockville, Maryland, that since 1986 has housed young chimpanzees for use by the nearby National Institutes of Health (NIH). Now an animal-advocacy group is demanding that the animals' roles as research subjects is brought to an end.

Researchers at the NIH?s National Institute of Allergy and Infectious Diseases (NIAID) and the Food and Drug Administration have used the juvenile chimpanzees to study hepatitis C and malaria, as well as other causes of human infection, such as respiratory syncytial virus and norovirus. But now the NIH?s demand for ready access to chimpanzees is on the wane as the scientists who relied on them retire and social and political pressures against their use grow. The four remaining chimps are set to be returned soon to their owner, the New Iberia Research Center (NIRC) near Lafayette, Louisiana.

?Much of what I have done over the past years has been research in chimps,? says Robert Purcell, 76, who heads the hepatitis viruses section at the NIAID?s Laboratory of Infectious Diseases. ?It?s just a good time now [to retire] as the chimps are essentially no longer available.?

Last December, a report from the US Institute of Medicine concluded that most chimpanzee research was scientifically unnecessary and recommended that the NIH sharply curtail its support. The agency has since set up a working group to review existing studies and advise on whether they should be ended. Purcell and his team have formally requested that one study on liver disease, involving three of the remaining chimps at Bioqual, should be allowed to continue.

But animal activists say that the Bioqual chimpanzees, which could undergo decades more research at the NIRC, should be retired. On 5 July, the Physicians Committee for Responsible Medicine (PCRM), an animal-advocacy group in Washington DC, launched a petition and wrote to NIH director Francis Collins urging him to intervene to ensure that the animals are placed in a federally supported sanctuary in Louisiana called Chimp Haven.

In reply, the NIH issued a statement noting that the Bioqual animals are leased, but not owned, by the agency. As a result, it said, ?NIH does not have authority over privately owned chimpanzees and cannot decide where they are placed?.

Travel costs
The NIRC, the chimps? owner, and part of the University of Louisiana at Lafayette, houses around 350 research chimpanzees and conducts studies on them for commercial clients. It has for decades leased young animals to NIAID. Thomas Rowell, the NIRC's director, could not be reached for comment.

The activists are also concerned because last year one chimpanzee, an 8-year-old male called Chaos, died during transit from Bioqual to the NIRC. The US Department of Agriculture, which enforces the Animal Welfare Act, is investigating the incident. Procedures have changed since; when eleven other chimps were shipped back to the NIRC last month, the truck was driven by a vet, and an animal technician rode with the animals.

The remaining four chimps at Bioqual are scheduled to be shipped back to the NIRC soon: Loretta, a three-year-old that has just completed a two-year study probing how malaria parasites resist chloroquine and artemisinin, two key drugs against the disease, will travel to Louisiana within weeks. Seven-year-old Ricky, with Tiffany and Torian, who are both four years old, will follow a few months later. Purcell is using them to study a possible infectious trigger of primary biliary cirrhosis, a chronic autoimmune disease of the liver that is usually fatal without a liver transplant.


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